Orlistat Capsules – 60mg x 160 tables

Orlistat is a medication used primarily for weight management. It’s known by the brand names Xenical (prescription) and Alli (over-the-counter). Here’s a detailed look at Orlistat:

• When meals contain fat, take 60 mg (1 tablet) orally with meals
• Do not exceed 3 capsules per day
• Pregnant and lactating women are prohibited
• It is contraindicated for patients with malabsorption syndrome and cholestasis
• It is contraindicated in patients who have received an organ transplant or are taking cyclosporine. Orlistat may interfere with medications used to prevent transplant rejection
• Patients who are allergic to orlistat or any of the ingredients in the drug preparation are contraindicated
• It is contraindicated in patients with organic obesity (such as hypothyroidism)

Mechanism of Action

Orlistat works by inhibiting the activity of enzymes called lipases, which are responsible for breaking down dietary fats in the intestine. By blocking these enzymes, Orlistat prevents the absorption of about 25-30% of the fat consumed in the diet. The undigested fat is then excreted in the stool.

Indications

1. Obesity Management: Orlistat is used as part of a comprehensive weight loss program that includes a reduced-calorie diet and increased physical activity. It is typically prescribed for individuals with a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with weight-related health conditions (like hypertension or type 2 diabetes).
2. Weight Maintenance: After achieving a significant weight loss, Orlistat may be used to help maintain the weight loss.

Dosage

• Prescription Form (Xenical): The typical dose is 120 mg taken three times daily with each main meal that contains fat. It’s important to take the medication during or up to 1 hour after a meal.
• Over-the-Counter Form (Alli): The dose is 60 mg taken three times daily with each main meal containing fat.

Side Effects

Orlistat can cause gastrointestinal side effects due to the unabsorbed fat passing through the digestive system. Common side effects include:

• Oily Stools: This can occur due to the undigested fat.
• Flatulence: Often with discharge.
• Frequent Bowel Movements: Including the possibility of urgency.
• Abdominal Cramping: Discomfort in the abdominal region.

Dietary Considerations

While taking Orlistat, it’s important to follow a balanced diet that contains no more than 30% of calories from fat. This helps minimize side effects and enhances the medication’s effectiveness.

Interactions

Orlistat may interact with other medications and vitamins, particularly fat-soluble vitamins (A, D, E, and K) and some medications for thyroid conditions and diabetes. It’s important to consult with a healthcare provider about potential interactions and to take vitamin supplements if needed.

Efficacy

Clinical studies have shown that Orlistat can help individuals lose weight when used in conjunction with a reduced-calorie diet. On average, it may help users lose 5-10% of their body weight over a year. However, individual results can vary.

Precautions

• Liver Function: There have been rare reports of severe liver injury; monitoring liver function might be necessary.
• Gallbladder: Orlistat may increase the risk of gallstones in some individuals.
• Pregnancy and Breastfeeding: The safety of Orlistat during pregnancy and breastfeeding hasn’t been established. It’s generally recommended to avoid using it during these times unless specifically advised by a healthcare provider.

Overall, Orlistat can be an effective tool for weight loss and maintenance when used properly and in conjunction with lifestyle changes. Always consult with a healthcare provider for personalized advice and to ensure it’s the right option based on individual health needs and conditions.