NMN18000 – Nicotinamide MonoNucleotide: 60 capsules

Nicotinamide Mononucleotide (NMN) is a naturally occurring molecule in the body that plays a critical role in cellular energy production and aging. It is a nucleotide derived from niacin (vitamin B3) and is a precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme found in all living cells.

Key Functions and Importance of NMN

1. NAD+ Synthesis:
   • NMN is directly involved in the biosynthesis of NAD+. NAD+ is crucial for various cellular processes, including energy metabolism, DNA repair, and cell survival. As we age, the levels of NAD+ in our cells decline, leading to reduced cellular function and increased vulnerability to age-related diseases.
2. Energy Metabolism:
   • NMN contributes to the production of NAD+, which is vital for mitochondrial function. Mitochondria are the powerhouses of cells, producing ATP, the energy currency of the cell. Adequate levels of NAD+ ensure efficient energy production, which is essential for maintaining cellular health and function.
3. DNA Repair:
   • NAD+ is required for the activity of enzymes called sirtuins and PARPs (poly ADP-ribose polymerases), which are involved in DNA repair. By increasing NAD+ levels, NMN indirectly supports the maintenance of genomic integrity, reducing the accumulation of DNA damage that occurs with aging.
4. Anti-Aging and Longevity:
   • Research has shown that supplementing with NMN can raise NAD+ levels, potentially reversing some aspects of cellular aging. Studies in animal models have demonstrated that NMN supplementation can improve metabolic function, enhance physical performance, and extend lifespan. This has made NMN a popular subject of research in the field of aging and longevity.
5. Cardiovascular Health:
   • NMN has been shown to improve blood vessel function, enhance blood flow, and reduce the risk of cardiovascular diseases. This is partly due to its role in boosting NAD+ levels, which supports endothelial cell function and reduces oxidative stress.

Sources of NMN

• NMN is found in small amounts in some foods, including:
  • Broccoli
  • Cabbage
  • Cucumbers
  • Avocados
  • Tomatoes
  • Edamame

  However, the quantities in these foods are typically low, and supplementation is often considered to achieve therapeutic levels.

NMN Supplementation

• Forms: NMN supplements are available in various forms, including capsules, powders, and sublingual tablets. The bioavailability of NMN (how well it is absorbed and utilized in the body) varies depending on the form.
• Dosage: There is no universally recommended dosage for NMN, as research is still ongoing. Doses in studies have ranged from 250 mg to 1,000 mg per day. It is advisable to consult with a healthcare provider before starting NMN supplementation.
• Safety: NMN is generally considered safe and well-tolerated, with few reported side effects. However, long-term safety data in humans is still limited, and more research is needed to fully understand its effects.

Current Research and Potential Benefits

• Aging: NMN is being investigated for its potential to delay or reverse age-related decline in various tissues, including the brain, heart, and muscles.
• Metabolic Disorders: Studies are exploring NMN’s potential to improve conditions like obesity, type 2 diabetes, and fatty liver disease by enhancing metabolic health.
• Neuroprotection: NMN may protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s by maintaining neuronal health and function.
• Exercise Performance: Research suggests that NMN can enhance endurance and strength by improving muscle energy metabolism.

Conclusion

Nicotinamide Mononucleotide (NMN) is a promising molecule in the field of anti-aging and metabolic health. Its role in boosting NAD+ levels makes it a key player in maintaining cellular energy, DNA repair, and overall health. While the science is still evolving, NMN supplementation holds potential for enhancing longevity and combating age-related diseases. However, it is important to approach NMN use with caution and under the guidance of a healthcare professional.